Research Article
Utility of Advance MR Imaging in Differentiation of Benign and Malignant Orbital Masses
Bansal A1, Kumar A1*, Bhatia V1, Singh U2, Ahuja CK1 and Nahar U3
1Department of Radiodiagnosis and Imaging, PGIMER, India
2Department of Opthalmology, PGIMER, India
3Department of Histopathology, PGIMER, India
*Corresponding author: Kumar A, Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh - 160012, India,
Phone: +91-7087009385; E-mail: ajay2509@gmail.com
Copyright: © 2021 Bansal A, et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
Article Information: Submission: 17/08/2021; Accepted: 10/11/2021; Published: 15/11/2021
Abstract
Aim: The purpose of this study was to evaluate the utility of advanced MR techniques to improve the diagnostic ability to differentiate between these
entities.
Material and Methods: A prospective evaluation of 26 patients (12 men and 14 women with a mean age of 34.8 years) presenting with orbital masses
to our institute was done. MRI was performed in all patients with advanced techniques DWI, MRS and dynamic (DCE) on a 1.5 T scanner.
Results: ADC cut off value of 0.809 x 10-3 mm2/sec was determined using the ROC curve to differentiate malignant from benign lesions resulting in
a sensitivity of 72.2% specificity of 75%, positive predictive value of 86.6% and Negative predictive value of 54.5%. Lesions with Tp < 141.5s showed a
sensitivity of ~94.4% and specificity of ~87.5%, positive predictive value of 94.4% and Negative predictive value of 87.5%for malignancy. The lesions with
Slope > 0.47 showed a sensitivity of ~100% and specificity of ~78%, positive predictive value of 66.6% and Negative predictive value of 100% for malignancy.
Significant difference was seen between type I and type III curves with a p value ~0.002. Presence of choline peak had a sensitivity of ~ 62.5%, specificity
of ~94.4%, positive predictive value of 83.3% and negative predictive value of 85% for malignancy.
Conclusion: Use of advanced MR imaging with inclusion of DW, MRS and perfusion parameters can significantly increase our diagnostic confidence in
differentiating benign from malignant orbital lesions.