Research Article
The Role of Statins in Stroke Management
Mahamankar A1*, Sonawane A2, Kotwal S3, Ramkumar R4 and Kannan S5
1Aditya Nursing Home, Mahad, Raigad, Near Shivaji Chowk, Maharashtra – 402301, India
2Sarthak Health Clinic, Near Shatabdi Hospital, Mumbai Naka, Renuka Nagar, Nashik, Maharashtra – 422001, India
3Government Medical College, Jammu, India
4Kamakashi Hospital, Pallikaranai, Chennai-600100, India
5NH Hospital, 258/A, Hosur Road Anekal Taluk, Bommasandra Industrial Area, Bengaluru, Karnataka 560099, India
*Corresponding author: Mahamankar A, Aditya Nursing Home, Mahad, Raigad, Near Shivaji Chowk, Maharashtra –
402301, India, Mobile : +91 9860996012, E-mail: dradityamhamnkar81@gmail.com
Article Information: Submission: 16/08/2021; Accepted: 23/09/2021; Published: 27/09/2021
Copyright: © 2021 Mahamankar A, et al. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited.
Abstract
Stroke is the second leading cause of death globally. Statins are the preferred drugs for management of dyslipidemia, a major risk factor for atherosclerosis.
In addition to their cholesterol-lowering effects, statins have been shown to have pleiotropic effect of being antithrombotic, anti-inflammatory, and providing
endothelial protection. The present review was performed to assess the role of statins in the prevention and management of stroke.
A PubMed search was conducted with the search terms ‘statins’ and ‘stroke’ for randomized controlled trials published between 2010 and 2020.
Abstracts were screened and relevant articles were selected. A search was then conducted on PubMed and Google Scholar with the search terms ‘statins’,
‘stroke’, ‘primary prevention’, ‘secondary prevention’, between 2010 and 2020 and relevant articles were selected. In a backward chronological search, the
reference lists of all the selected articles were checked and other relevant articles were selected. The selected papers were used to evaluate the role of statins
in the prevention and management of stroke.
The narrative review discusses the role of statins in primary and secondary prevention of stroke, role of intensive statin therapy and the economic
implications of statins for the prevention of stroke.
It was concluded that statins have known role in reducing cholesterol levels, and primary and secondary prevention trials have time and again shown
the beneficial effects of statins in the prevention and management of stroke. Treatment with statins could be more cost-effective if low-risk patients are
aggressively treated, and guidelines consider the therapy for a broader patient population.