Review Article
The Gut Skin Connection in Acne and Rosacea: Therapeutic Roles of Probiotics and Prebiotics
Sushmitha VL*, Madalagiri D and Chennappa G
Department of Food Technology, MS Ramaiah University of Applied Sciences, M S R Nagar, Mathikere, Bengaluru, Karnataka India
*Corresponding author: Dr. Sushmitha VL, Department of Food Technology, MS Ramaiah University of Applied Sciences, New Bellary Rd, M S R Nagar, Mathikere, Bengaluru, Karnataka India. Email Id: dr.sushmithaprajwal@gmail.com, dr.sushmithavl.93@gmail.com
Article Information: Submission: 29/05/2025; Accepted: 20/06/2025; Published: 24/06/2025
Copyright: © 2025 Sushmitha VL, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Acne and rosacea are chronic inflammatory skin disorders increasingly linked to disturbances in the gut-skin axis. This review explores how probiotics and prebiotics modulate immune responses, enhance epithelial barrier function, and influence gut and skin microbiota to improve dermatological outcomes.
Clinical and mechanistic evidence shows that specific strains and fibers reduce inflammatory markers, lesion counts, and symptoms such as erythema and sensitivity. Oral and topical formulations demonstrate promise as adjunctive therapies. Despite encouraging findings, standardized clinical trials and personalized approaches are needed to fully integrate microbiome-targeted strategies into dermatology for the effective management of acne and rosacea.
Keywords: Probiotics; Prebiotics; Acne; Rosacea; Gut-Skin Axis; Inflammation