Research Article
MRI Features of Different Molecular subtypes of Breast Cancer
Issar P1*, Sinha S2, Ravindranath M3 and Issar SK4
1Department of Radiodiagnosis, JLN Hospital and Research Centre, India
2Department of Radiodiagnosis, KIMS Superspeciality Hospital, India
3Depetment of Pathology, JLN Hospital and Research Centre, India
4Director In-charge, JLN Hospital and Research Centre, India
*Corresponding author: Issar P, HOD Radiodiagnosis, JLN Hospital and Research Centre Bhilai Chhattisgarh, DB-8, Talpuri, Bhilai, Chhattisgarh, 490009, Tel: 9407983540; Email: mareesh_23@yahoo.co.in
Copyright: © 2020 Issar P, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Information: Submission: 25/06/2020; Accepted: 04/09/2020; Published: 10/09/2020
Abstract
Background: Molecular subtypes of breast cancer have different imaging findings on MRI.
Aim: To assess the MRI features of different molecular subtypes of breast cancer.
Setting and Design: A retrospective observational study.
Materials and Methods: 82 patients with histopathologically confirmed breast cancer along with immunohistochemistry were included in this study. MRI
was performed with a 1.5 T Scanner (Signa excite GE healthcare) using a dedicated 8 channel breast coil. MRI findings were correlated with the different
molecular subtypes of breast cancer. Statistical Analysis was performed with statistical software SPSS 17.0, p-Value < 0.05 were considered significant.
Results: The molecular subtypes distribution was Luminal A in 48.78%, Luminal B in 9.76%, Human Epidermal Receptor 2 positive (HER2+) in 14.64%
and Triple Negative Breast Cancer (TNBC) in 26.82% of the patients. Luminal A subtype presented mainly as a mass lesion with an irregular shape, spiculated
margin, and heterogeneous enhancement. TNBC was mainly showing high intratumoral signal intensity (p=0.0003),unifocal lesion (p=0.0002), round or oval
(p=0.006), smooth margin, rim enhancement and having high ADC value (p=0.017). Multifocal or non-mass lesion along with axillary adenopathy, skin,
peritumoral, and prepectoral edema was found to be more common in Luminal B and HER2+ subtypes.
Conclusion: Breast MR Imaging can help in assessing different molecular subtypes of breast cancer, especially in Luminal A, as an irregular mass with spiculated margin and round or oval mass with rim enhancement and high ADC value in TNBC. Multifocal masses with adenopathy and skin involvement in Luminal B and HER2+ molecular subtypes.