Research Article
Isolation of Flavonoids from Ocimum sanctum L. and its Docking Study as Angiotensin Converting Enzyme (ACE) Inhibitors
Patel H* and Gamit D
Department of Biosciences, Veer Narmad South Gujarat University, India
*Corresponding author: Patel H, Department of Biosciences, Veer Narmad South Gujarat University, Surat, Gujarat, India, Email: hinalbiotech@gmail.com
Copyright: © Patel H, et al. 2020. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Information: Submission: 07/02/2020; Accepted: 16/03/2020; Published: 20/03/2020
Abstract
Hypertension is one of the most common health problems that carry a high risk of stroke, myocardial infection and renal disease. ACE is one of the important enzymes that responsible for hypertension. Ocimum sanctum plant is very important for their therapeutic potential. There are so many phytochemicals are present in Ocimum sanctum among which flavonoids are most important for their health benefits. In present study prepared flavonoid extract from Ocimum sanctum leaves using methanol and ethyl acetate solvent. Isolate flavonoids from prepared solvent extract using preparative HPTLC method and identified it with the help of HRLC-MS/Q-TOF technique. Molecular docking study was conducted using iGEMDOCK V.2 windows software to
find out efficiency of isolated flavonoids with ACE along with standard drug. This information can be further utilized for design of potential therapeutic drug from plant flavonoid in regulation of hypertension.