Medicinal plants are a gift to humankind as they play a significant role in preserving, maintaining, and improving our health. Aerva lanata has been known for decades for its various pharmacological activities. Despite extensive research on its medicinal properties, there have been limited studies focusing on its hepatoprotective activity. This study aims to explore the bioactive components of Aerva lanata and investigate its potential hepatoprotective properties. The review utilized various scientific databases, including PubMed and ScienceDirect, to gather information on the pharmacological activities and bioactive components of Aerva lanata. The whole plant methanolic extract of Aerva lanata was subjected to preliminary phytochemical analysis, revealing the presence of alkaloids, flavonoids, phenols, glycosides, and tannins. High-Performance Thin-Layer Chromatography (HPTLC) was used to identify prominent compounds, followed by High Resolution Liquid Chromatography-Mass Spectrometry Orbitrap (HR-LCMS, Orbitrap) for detailed component analysis. The HPTLC chromatogram indicated significant spots at Rf values of 0.026, 0.075, 0.096, 0.46, and 0.82. HR-LCMS analysis revealed several medicinally important compounds, including norharman, 10-hydroxycanthin-6-one, 9-methoxycanthin-6-one, trigonelline, methylquinoline, 8-hydroxyquinoline, quercetin, kaempferol, rutin, and artemisinin. These findings support the traditional uses of Aerva lanata and suggest the potential for new drug discoveries. The study concludes that Aerva lanata contains several bioactive compounds with medicinal properties, justifying its traditional applications. Further research is needed to fully understand its hepatoprotective mechanisms and explore new therapeutic possibilities.

Keywords:Aerva lanata; HR-LCMS; Hepatoprotective; Medicinal Plants; Phytochemicals