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Indian Journal of Neurology

Case Report

Epstein–Barr Virus Meningoencephalitis Presenting with Extrapyramidal Symptoms in an Immunocompetent Adult Female: A Rare Case Report

Bhargav NP*, Naik KR, Saroja AO, Makandar Kutub, Sumanth CV and Triveni Ayanna

Department of Neurology, Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and MRC, Belagavi, Karnataka, India
*Corresponding author:Dr. Bhargav NP, Department of Neurology, Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and MRC, Belagavi, Karnataka, India. E-mail Id: npbhargav4271@gmail.com
Article Information:Submission: 07/08/2025; Accepted: 22/09/2025; Published: 26/09/2025
Copyright: © 2025 Bhargav NP, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Epstein–Barr virus (EBV) is an infrequent yet important cause of meningoencephalitis, especially in immunocompetent individuals. [1] We present young patient, previously healthy woman who developed progressive neuropsychiatric and motor symptoms following a ritualistic holy dip. Her course wascomplicated by rural tremors, dystonia, rigidity, and quadriparesis. Despite broad-spectrum antimicrobial and antiviral therapy, the clinical response was initially limited. CSF polymerase chain reaction (PCR) ultimately revealed EBV as the causative pathogen. The patient underwent prolonged hospitalization with supportive neuro-rehabilitative care and gradual clinical recovery. This case emphasizes the need for high suspicion of EBV in atypical neuro-infections and the importance of early PCR-based diagnosis.