Research Article
Effect of Zinc Supplementation on Fasting Blood Glucose Level of Type 2 Diabetic Subjects
Silky1* and Gita Bisla2
Department of Food Science and Nutrition, Banasthali Vidyapith, Rajasthan, India
*Corresponding author:Silky Sharma, Department of Food Science and Nutrition, Banasthali Vidyapith, Rajasthan, India. E-mail Id: sharmasilky3003@gmail.com
Article Information:Submission: 29/08/2024; Accepted: 13/09/2024; Published: 16/09/2024
Copyright: © 2024 Silky, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction:The role of zinc in incidence of diabetes has been established. Supplementation of zinc has been found to improve insulin level and fasting glucose level. Pumpkin (Cucurbita pepo) seeds are an excellent source of zinc, protein and also have pharmacological activities such as antidiabetic, antihypertensive, antibacterial and antioxidant effects.
Objectives:The aim of present study, to evaluate serum Zn level in normal and type-2 diabetic patients and to assess the effect of zinc food supplementation in the improvement in the control of blood glucose level.
Methodology:In the study normal (n-30) and type-2 diabetic (n-30) volunteer subjects of both genders (age 35-50 years) enrolled for the study. All normal and diabetic subjects were screened for FBG and serum Zn level, to find out if there is any correlation between serum Zn level and FBG level. Then the group of diabetic subjects was supplemented biscuits prepared by incorporation of defatted pumpkin seeds powder with 3mg/day zinc content.Intervention was done for 45 days. All diabetic subjects were screened after zinc supplementation for FBG and serum Zn level, to compare both normal and diabetic subjects to assess the effect of zinc in diabetic subjects FBG level again.
Results:The results revealed that the mean of serum Zn level in normal subjects was101.37±25.76μg/dl and diabetic subjects it was 62.70±11.74μg/dl. The mean of FBG in normal subjects was 99.27±8.40mg/dl and in diabetic subjects was 135.94±13.51mg/dl. After the supplementation of zinc in diabetic subjects in serum zinc level was increased to 112.89±17.04μg/dl and FBG decreased to 109.86±32.97mg/dl and these changed were significantly at 1% level of significance.
Conclusion:Zinc supplementation produce a significant improvement in glucose disposal and increase activities of insulin independent glucose transporters. So, in study the role of zinc has been found to be associated with the improvement of glycemic control.
Objectives:The aim of present study, to evaluate serum Zn level in normal and type-2 diabetic patients and to assess the effect of zinc food supplementation in the improvement in the control of blood glucose level.
Methodology:In the study normal (n-30) and type-2 diabetic (n-30) volunteer subjects of both genders (age 35-50 years) enrolled for the study. All normal and diabetic subjects were screened for FBG and serum Zn level, to find out if there is any correlation between serum Zn level and FBG level. Then the group of diabetic subjects was supplemented biscuits prepared by incorporation of defatted pumpkin seeds powder with 3mg/day zinc content.Intervention was done for 45 days. All diabetic subjects were screened after zinc supplementation for FBG and serum Zn level, to compare both normal and diabetic subjects to assess the effect of zinc in diabetic subjects FBG level again.
Results:The results revealed that the mean of serum Zn level in normal subjects was101.37±25.76μg/dl and diabetic subjects it was 62.70±11.74μg/dl. The mean of FBG in normal subjects was 99.27±8.40mg/dl and in diabetic subjects was 135.94±13.51mg/dl. After the supplementation of zinc in diabetic subjects in serum zinc level was increased to 112.89±17.04μg/dl and FBG decreased to 109.86±32.97mg/dl and these changed were significantly at 1% level of significance.
Conclusion:Zinc supplementation produce a significant improvement in glucose disposal and increase activities of insulin independent glucose transporters. So, in study the role of zinc has been found to be associated with the improvement of glycemic control.
Keywords:Diabetes; Pumpkin; Zinc;Biscuits; Supplements