Zinc is an important micronutrient and is listed as an essential trace element which is required to maintain the smooth functioning of the immune system. Zinc has a vital role in ensuring normal development of innate immunity, neutrophils, and Natural Killer (NK) cells and warrants smooth functioning of the cells modulating them. Zinc deficiency impacts the function of macrophages, T and B cells, and cytokine production. It acts as a second messenger in the immune cells and participates in various signaling pathways including activation of T cells via T cell receptor and by the cytokine interleukin (IL)-2 pathway. Zinc is required by the pathogens for survival, hence in case of an infection, host body limits the zinc in the milieu by altering zinc distribution. Zinc has also been linked with antiviral properties against a wide variety of viruses, specifically RNA viruses such as rhinovirus, respiratory syncytial virus, and SARS-CoV. Zinc is naturally available from a myriad of foods sources. However, it can be taken as supplements by people who are not able to meet the required daily amount through food. Clinical studies have proven the health benefit of zinc supplements to address the deficiency as well as to ensure zinc-dependent physiological functions run smoothly. In this review, the role of zinc in immunity and importance of zinc supplementation has been explored.