Antibiotics and their importance in our life is established fact. Antibiotics are mainly used in infectious diseases to stop the bacterial and other microorganisms growth. But along with time many microbes have evolved intrinsic mechanism of antimicrobial resistance (AMR) due to indiscriminate and irrational use of antibiotics, thus become less susceptible to medical treatment. Resistance develops in bacteria by target modification, antibiotic inactivation, plasmidic efflux and efflux pump. Antimicrobial resistance is an upcoming threat to human society. Antimicrobial resistance (AMR), causes an estimated 700,000 deaths annually in the world and it is potentially affecting every country. So, its need of time to proper addresses this problem to avoid roar of silent pandemic in the future. The present scenario directs us to search for natural alternatives to antibiotics as well as a sensible use of antibiotics. Plant-derived antimicrobials can be the best alternative for this problem. Using the approach of traditional medicines against antimicrobial resistance can be overcome by expanding the screening of medicinal plants for phytochemicals present in them.