Herbal drugs have always remained an important source of medicine. As per the Indian traditional system of medicine, many medicinal plants have been used for the management of various health disorders, including diabetes mellitus. Diabetes mellitus is a non-communicable disease that is also referred to as a lifestyle disorder that requires modifications in diet, exercise, and behavior along with medication. Allium sativum (Garlic), Azadirachta indica (Neem), Phyllanthus emblica (Amla), Tamarindus indica (Imli), and Zingiber officinale (Ginger) are well-known and widely used medicinal plants in the world. Diabetic rats (FBS above 150 mg/dl) were treated orally with three different multiherbal formulations (F1, F2, and F3) at a dose of 300 mg/kg, once per day for 45 days. At the end of the study, their effects on the histology of the pancreas were evaluated. Pancreatic β cell regeneration of the multiherbal formulation (F2) was approximately equal to that of the standard drug. This study aimed to evaluate the possible effects of multiherbal formulations of these five plants on alloxan-induced diabetic rats.

Keywords:Diabetes Mellitus; Multiherbal Formulations; Histological Studies