Tuberculosis (TB) is a common disease in developing countries but isolated Pancreatic tuberculosis is an extremely rare entity even in endemic areas. It is often misdiagnosed due to a low index of suspicion and masquerading of its symptoms with more common pancreatic malignancy. The clinical and radiological features resemble malignancy, making diagnosis a clinical challenge. The definitive diagnosis rests on histologic and bacteriologic evidence of TB. Excellent cure rates are reported with standard anti-tubercular therapy given for 6–12 months. We discuss two cases of pancreatic TB successfully diagnosed and treated and their relevant literature.

Keywords:Isolated pancreatic TB, Abdominal tuberculosis